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Int J Mol Sci ; 21(9)2020 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-32349337

RESUMO

Risk stratification and accurate patient prognosis are pending issues in the management of patients with kidney disease. The furosemide stress test (FST) has been proposed as a low-cost, fast, safe, and easy-to-perform test to assess tubular integrity, especially when compared to novel plasma and urinary biomarkers. However, the findings regarding its clinical use published so far provide insufficient evidence to recommend the generalized application of the test in daily clinical routine. Dosage, timing, and clinical outcomes of the FST proposed thus far have been significantly different, which further accentuates the need for standardization in the application of the test in order to facilitate the comparison of results between series. This review will summarize published research regarding the usefulness of the FST in different settings, providing the reader some insights about the possible implications of FST in clinical decision-making in patients with kidney disease and the challenges that research will have to address in the near future before widely applying the FST.


Assuntos
Injúria Renal Aguda/diagnóstico , Injúria Renal Aguda/urina , Biomarcadores , Furosemida/farmacocinética , Testes de Função Renal/métodos , Inibidores de Simportadores de Cloreto de Sódio e Potássio/farmacocinética , Injúria Renal Aguda/etiologia , Injúria Renal Aguda/terapia , Tomada de Decisão Clínica , Gerenciamento Clínico , Furosemida/efeitos adversos , Furosemida/uso terapêutico , Humanos , Transplante de Rim , Prognóstico , Inibidores de Simportadores de Cloreto de Sódio e Potássio/efeitos adversos , Inibidores de Simportadores de Cloreto de Sódio e Potássio/uso terapêutico , Estresse Fisiológico
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